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What it is: Clinique's most advanced anti-aging serum with peptides and advanced retinoid. The serum helps reduce wrinkles, visibly lift, smooth, firm and boost radiance.
Who it's for: Ideal for all skin types.
What it does: Clinique's best wrinkle serum targets signs of aging from three separate angles. It helps strengthen skin to reduce the look of wrinkles and accelerates cell turnover to visibly smooth skin. The serum also replumps by hydrating skin and instantly minimizing the appearance of fine, dry lines. The serum is suitable for post-procedure skin*.
*It is shown safe for use following Intense Pulsed Light (IPL) treatment in 2-week clinical usage test.
Key ingredients:
- Peptides: CL1870 Peptide Complex™ helps boost skin’s strength for a smoother appearance. Leveraging Clinique’s 35 years of peptide expertise, their formula includes self-assembly, neuropeptide and signaling peptides: palmitoyl tripeptide-1, acetyl hexapeptide-8, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12
- Advanced retinoid: The next generation of retinol, formulated for high performance and gentle enough to use twice a day. Helps accelerate skin’s natural cell renewal to visibly reduce wrinkles
- Hyaluronic acid: instantly hydrates and plumps skin, helping minimize the look of fine, dry lines. Helps restore a youthful, supple appearance
Research results:
In a consumer test on 358 women after 10 days of use:
- 94% say skin feels smoother
- 90% say sin feels firmer
- 90% say skin looks more radiant
In a consumer test on 354 women after 4 weeks of use:
- 86% say skin looks lifted
- 88% agree it's gentle and nonirritating
In a clinical study after 16 weeks, women who had one laser treatment showed the same improvement in the overall look of lines and wrinkles as those who used Smart Serum twice daily instead. Laser used: microablative, deka dot SmartSkin CO2™ (Cynosure, Westford, MA) with CO2 fractional tech.
How to use: Use anti-wrinkle serum morning and night. Spread 1–2 pumps all over clean face and neck with fingertips, avoiding eye area. Follow with your favorite Clinique Smart Clinical Repair™ Moisturizer (sold separately).
Pro tips: Daily sunscreen is imperative. Limit sun exposure while using and the week after. Do not use with other retinol products.
- Paraben-free; phthalate-free; sulfate-free; fragrance-free, oil-free; drying alcohol–free
- Dermatologist tested and developed
- Safe for sensitive skin
- Allergy tested
- Made in the USA
Eligible Rack purchases made between 10/5/26 and 12/24/26 can be returned by 1/18/27 or 40 days after purchase—whichever is later. Online purchases: eligible items can be returned by mail or to a Nordstrom Rack or Nordstrom store. Store purchases: eligible items can be returned to a Nordstrom Rack or Nordstrom store. All returns are subject to our return policy terms.
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