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Main content
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Brooks Glycerin 21 Running Shoe, Main, color,
Brooks Glycerin 21 Running Shoe, Alternate, color,
Glycerin 21 Running Shoe, sales video thumbnail
Brooks Glycerin 21 Running Shoe, Alternate, color,
Brooks Glycerin 21 Running Shoe, Alternate, color,
Brooks Glycerin 21 Running Shoe, Alternate, color,

Glycerin 21 Running Shoe (Men)

Brooks

Men

SOLD OUT

This item is no longer available. Browse our recommendations for something similar.

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Details & care

Designed with maximized cushioning for a soft, plush ride, this everyday running shoe keeps you going for miles on signature nitrogen-infused DNA LOFT v3 foam. A breathable warp knit in the upper wraps your foot in flexible comfort, while the wider base helps stabilize your stride from heel to toe.

  • Neutral: provides soft, even cushioning with an emphasis on comfort during any activity
  • Lace-up style
  • Removable, cushioned insole allows for custom orthotics
  • DNA LOFT v3 nitrogen-infused cushioning pairs responsive performance with soft, lightweight comfort
  • Textile and synthetic upper and lining/rubber and synthetic sole
  • Imported
  • Item #10028896
Helpful info:
(video)
Athletic Shoe Fit Guide

Size info

  • True to size.

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Brooks

Brooks was founded in 1914 in Philadelphia before moving to Seattle, where the company is headquartered today. Brooks running shoes are designed with specialized high-tech features like DNA midsoles for adaptive cushioning and 3D Fit Print for lightweight, flexible structure. The brand also offers running clothing to make sure you're fully outfitted for any run.

Reviews

(503)
4.2 out of 5
Write a Review
Fit: True to size
Width: True to width

Most helpful positive review

Feb 14, 2026
Great Shoe
[This review was collected as part of a promotion.] First off, not a runner due to back injuries. Second, I bought these mostly to exercise in. That means biking, treadmill, and gym. Perfect fit, laterally stable, great cushioning, and I love the color scheme and design.
PaulB
Reposted from brooksrunning.com

Most helpful critical review

Nov 22, 2025
hurt toe, :(
[This review was collected as part of a promotion.] I like mine, they are beautiful, but after using Ghosts, Hyperion and this is my second glycerin, they hurt my second toe of the left foot.
AlejandroS
Reposted from brooksrunning.com

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5 stars
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4 stars
13%
3 stars
8%
2 stars
7%
1 star
8%
Sort by Most Helpful
PaulB
Reposted from brooksrunning.com
Feb 14, 2026
Great Shoe
[This review was collected as part of a promotion.] First off, not a runner due to back injuries. Second, I bought these mostly to exercise in. That means biking, treadmill, and gym. Perfect fit, laterally stable, great cushioning, and I love the color scheme and design.
AlejandroS
Reposted from brooksrunning.com
Nov 22, 2025
hurt toe, :(
[This review was collected as part of a promotion.] I like mine, they are beautiful, but after using Ghosts, Hyperion and this is my second glycerin, they hurt my second toe of the left foot.
James123
Reposted from brooksrunning.com
July 19, 2025
I recently picked up the Brooks Glycerin 21 after my go-to shoe, the Brooks Adrenaline, was out of stock. I was told the Glycerin was a good alternative, but unfortunately, it didn’t live up to that promise—at least not for me. Right out of the box, the Glycerin 21 felt plush and well-cushioned, which initially gave me hope. However, once I started running, the comfort quickly disappeared. The fit felt off, especially around the arch and heel, and I noticed discomfort within the first couple of miles. After a few runs, the pain in my feet became consistent enough that I had to stop using them altogether. To be fair, the Glycerin 21 might work well for runners who prefer a softer, more neutral shoe, but if you're coming from the Adrenaline—especially if you rely on the stability features—it’s just not the same experience. I felt like I had less support, which may have contributed to the discomfort during runs. Overall, I wouldn't recommend the Glycerin 21 as a substitute for the Adrenaline, especially if foot support and comfort are high priorities for you. Hopefully, the Adrenaline comes back in stock soon because this one just didn’t work for me.
Johnny Shoebuyer
Verified purchase
Fit:

Small
True to size
Large
Width:

Narrow
True to width
Wide
July 1, 2025
Disappointed
Wore these one time. Second time the eyelet ripped out when I was tieing them
Was this helpful?
RaeannG
Verified purchase
Fit:

Small
True to size
Large
Width:

Narrow
True to width
Wide
June 8, 2025
Husband is happy!
My husband loves these and they were such a good price!
Was this helpful?
ChrisK
Reposted from brooksrunning.com
June 8, 2025
Good fit and feel.
I've gotten in about 10 outside runs (3-6 miles) now. Good fit and feel. I am more of a stability and support guys versus super cushioning. It's been my new go-to pair.
Load 6 more reviews
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